Andrographolide : Potency as Antiatherosclerosis in Il-1β Cytokine
Abstract
The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, as it is known that cytokines regulate complex inflammatory responses in atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) is a plant with various pharmacological activities. Andrographolide (AND) is the main bioactive compound in the diterpene lactone group. This literature study aims to assess the potential of AND on the proinflammatory cytokine IL-1 β as an antiatherosclerosis. This type of research is a qualitative review of various studies using sambiloto plants or andrographolide compounds (AND). Search literature using the Google Scholar database. Keywords used "Andrographis paniculata, andrographolide, IL-1β, Atherosclerosis. The results showed that AND has effects as an anti-inflammatory, antiatherosclerosis as well as cardiovascular-related diseases. There are not many articles on the activity of AND in IL-1β against atherosclerosis, but AND can provide inhibitory activity of the cytokine IL-1β against inflammation. Not many researchers have discussed the pharmacological effects of AND as an antiatherosclerotic on IL-1β therapeutic targets, but from the results of the review AND has a strong potential in inhibiting IL-1 cytokine secretion β.
Downloads
References
A. P. Hendrata, K. Handono, H. Kalim, and L. E. Fitri, “Andrographis paniculata can modulate the ratio of Treg to Th17 cells in atherosclerotic rats,” Clinical Nutrition Experimental, vol. 20, pp. 20–29, 2018, doi: 10.1016/j.yclnex.2018.05.002.
R. Mota, J. W. Homeister, M. S. Willis, and E. M. Bahnson, “Atherosclerosis: Pathogenesis, Genetics and Experimental Models,” in eLS, 2017, pp. 1–10. doi 10.1002/9780470015902.a0005998.pub3.
S. Barquera et al., “Global Overview of the Epidemiology of Atherosclerotic Cardiovascular Disease,” Archives of Medical Research, vol. 46, no. 5, pp. 328–338, Jul. 2015, doi: 10.1016/j.arcmed.2015.06.006.
S. Barquera et al., “Global Atlas on cardiovascular disease prevention and control,” Archives of Medical Research, vol. 46, no. 5, pp. 328–338, Jul. 2015, doi: 10.1016/j.gheart.2018.09.511.
K. J. Moore and I. Tabas, “Macrophages in the pathogenesis of atherosclerosis.,” Cell, vol. 145, no. 3, pp. 341–355, 2011, doi: 10.1016/j.cell.2011.04.005.The.
Di. Tousoulis, E. Oikonomou, E. K. Economou, F. Crea, and J. C. Kaski, “Inflammatory cytokines in atherosclerosis: Current therapeutic approaches,” European Heart Journal, vol. 37, no. 22, pp. 1723–1735, 2016, doi: 10.1093/eurheartj/ehv759.
F. Merhi-Soussi et al., “Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice,” Cardiovascular Research, vol. 66, no. 3, pp. 583–593, 2005, doi: 10.1016/j.cardiores.2005.01.008.
A. R. Fatkhullina, I. O. Peshkova, and E. K. Koltsova, “The role of cytokines in the development of atherosclerosis,” Biochemistry (Moscow), vol. 81, no. 11, pp. 1358–1370, 2016, doi: 10.1134/S0006297916110134.
Y. P. Nagaraja and V. Krishna, “Hepatoprotective effect of the Aqueous Extract and 5-Hydroxy, 7,8,2′ Trimethoxy Flavone of Andrographis alata Nees. in Carbon Tetrachloride Treated Rats,” Achievements in the Life Sciences, vol. 7, pp. 1–6, 2016.
W. Zou et al., “The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-ΚB pathway,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, pp. 1–7, 2016, doi: 10.1186/s12906-016-1466-5.
N. K. Warditiani, N. M. P. Susanti, C. I. S. Arisanti, N. P. R. D. Putri, and I. M. A. G. Wirasuta, “Antidyslipidemia and Antioxidant Activity of Andrographolide Compound From Sambiloto (Andrographis Paniculata) Herb,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 7, p. 59, 2017, doi: 10.22159/ijpps.2017v9i7.18109.
R. Kleemann, S. Zadelaar, and T. Kooistra, “Cytokines and atherosclerosis: A comprehensive review of studies in mice,” Cardiovascular Research, vol. 79, no. 3, pp. 360–376, 2008, doi: 10.1093/cvr/cvn120.
J. W. E. Moss and D. P. Ramji, “Cytokines: Roles in atherosclerosis disease progression and potential therapeutic targets,” Future Medicinal Chemistry, vol. 8, no. 11, pp. 1317–1330, 2016, doi: 10.4155/fmc-2016-0072.
Y. Li et al., “Andrographolide Inhibits Inflammatory Cytokines Secretion in LPS-Stimulated RAW264.7 Cells through Suppression of NF-κB/MAPK Signaling Pathway,” Evidence-based Complementary and Alternative Medicine, vol. 2017, 2017, doi: 10.1155/2017/8248142.
R. Al Batran, F. Al-Bayaty, M. M. Jamil Al-Obaidi, S. F. Hussain, and T. Z. Mulok, “Evaluation of the effect of andrographolide on atherosclerotic rabbits induced by Porphyromonas gingivalis,” BioMed Research International, vol. 2014, 2014, doi: 10.1155/2014/724718.
M. T. Nguyen, S. L. Verweij, F. M. Van Der Valk, and E. S. G. Stroes, “Inflammation as a Therapeutic Target in Atherosclerosis,” Journal of Clinical Medicine, vol. 8, no. 1109, pp. 1–20, 2019, doi 10.1097/MOL.0000000000000233.
J. Shu, R. Huang, Y. Tian, Y. Liu, R. Zhu, and G. Shi, “Andrographolide protects against endothelial dysfunction and inflammatory response in rats with coronary heart disease by regulating ppar and nf-κb signalling pathways,” Annals of Palliative Medicine, vol. 9, no. 4, pp. 1965–1975, 2020, doi: 10.21037/apm-20-960.
C. V. Chandrasekaran, A. Gupta, and A. Agarwal, “Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro,” Journal of Ethnopharmacology, vol. 129, no. 2, pp. 203–207, 2010, doi: 10.1016/j.jep.2010.03.007.
Y. Li et al., “Andrographolide Inhibits Inflammatory Cytokines Secretion in LPS-Stimulated RAW264.7 Cells through Suppression of NF-κB/MAPK Signaling Pathway,” Evidence-based Complementary and Alternative Medicine, vol. 2017, no. June 2017, doi: 10.1155/2017/8248142.
N. Kim et al., “Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and acute murine colitis through activating AMPK,” Biochemical Pharmacology, vol. 170, no. August, p. 113646, 2019, doi 10.1016/j.bcp.2019.113646.
T. Zhu et al., “Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB,” PLoS ONE, vol. 8, no. 2, 2013, doi: 10.1371/journal.pone.0056407.
A. K. Thakur, U. K. Soni, G. Rai, S. S. Chatterjee, and V. Kumar, “Andrographolide Modulate some Toll-like Receptors and Cytokines Expressions in HL-60 Cell Line,” Pharmacy & Pharmacology International Journal, vol. 2, no. 4, pp. 116–120, 2015, doi: 10.15406/ppij.2015.02.00027.
S. Xu et al., “Salvianolic acid B inhibits platelets-mediated inflammatory response in vascular endothelial cells,” Thrombosis Research, vol. 135, no. 1, pp. 137–145, 2015, doi: 10.1016/j.thromres.2014.10.034.
M. Liu et al., “β-Elemene attenuates atherosclerosis in apolipoprotein E-deficient mice via restoring NO levels and alleviating oxidative stress,” Biomedicine and Pharmacotherapy, vol. 95, no. July, pp. 1789–1798, 2017, doi: 10.1016/j.biopha.2017.08.092.
H. T. Wang et al., “Patchouli alcohol attenuates experimental atherosclerosis via inhibiting macrophage infiltration and its inflammatory responses,” Biomedicine and Pharmacotherapy, vol. 83, pp. 930–935, 2016, doi 10.1016/j.biopha.2016.08.005.
B. He et al., “Fistular onion stalk extract exhibits anti-atherosclerotic effects in rats,” Experimental and Therapeutic Medicine, vol. 8, no. 3, pp. 785–792, 2014, doi: 10.3892/etm.2014.1790.
C. Prachar, F.-J. Kaup, and S. Neumann, “Interleukin-1 Beta (IL-1< i>β</i>) in the Peripheral Blood of Dogs as a Possible Marker for the Detection of Early Stages of Inflammation,” Open Journal of Veterinary Medicine, vol. 03, no. 07, pp. 302–308, 2013, doi: 10.4236/ojvm.2013.37049.
M. Y. Hamidy, “Mekanisme Kerja dan Target Molekuler Interleukin-1 receptor antagonist ( Anakinra ) pada Aterosklerosis,” JIK, vol. 11, no. 2, pp. 59–64, 2017.
G. B. Lim, “Research Highlights Inflammation & Myocardial Infarction,” 2019.
Copyright (c) 2023 Putu Yudha Ugrasena, Iwan Saka Nugraha, Ni Wayan Rika Kumara Dewi
This work is licensed under a Creative Commons Attribution 4.0 International License.
3.png){kind=logo}
