Lifestyle Interventions on Prevention of Type 2 Diabetes Mellitus in Pre-Diabetes Patients

Fitriani Fitriani, Sanghati Sanghati

  • Fitriani Fitriani STIK Makassar
  • Sanghati Sanghati STIK Makassar
Keywords: pre diabetes, diabetes mellitus type 2, lifestyle interventions


Introduction: Pre-diabetes is a condition where blood glucose levels are above normal, but do not meet the standard to be diagnosed as diabetes. This literature review aims to determine the effectiveness of lifestyle interventions in preventing the risk of developing type 2 diabetes in pre-diabetic patients. Methods: Search articles using five databases, namely Pubmed, Proquest, ScienceDirect, Cochrane Library and Google Scholar identified 21,380 articles. Results: Five studies that met the criteria showed that lifestyle interventions were effective in preventing the risk of developing type 2 diabetes in pre-diabetic patients. Four studies reported no participant developing type 2 DM and only one study reported progression of pre-diabetes to type 2 DM, but overall it was greater in the control group than in the treatment (22.8% vs 15.0%). At the age of 18-64 years, lifestyle interventions can reduce the risk of diabetes in two years by 30%, in the following years 40% and 10%, respectively. While at the age of 65-84 years from 40% to 50% in the first two years and from 10% to 20% in the following years. Conclusion: Based on the results of a review of five articles, it was concluded that lifestyle interventions can effectively prevent the risk of developing type 2 diabetes in pre-diabetic patients


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Author Biographies

Fitriani Fitriani, STIK Makassar

Program Studi D-III Keperawatan

Sanghati Sanghati, STIK Makassar

Program Studi D-III Keperawatan


Aguiar, E. J., Morgan, P. J., Collins, C. E., Plotnikoff, R. C., Young, M. D., & Callister, R. (2016). Efficacy of the Type 2 Diabetes Prevention Using LifeStyle Education Program RCT. American Journal of Preventive Medicine, 50(3), 353–364.

Ali, M. K., Echouffo-Tcheugui, J., & Williamson, D. F. (2012). How Effective Were Lifestyle Interventions in Real-World Settings that Were Modeled on the Diabetes Prevention Program? Health Affairs, 31(1), 67–75.

American Diabetes Association. (2018). Diabetes Care: Standards Of Medical Care In Diabetes 2018. Diabetes Care, 41(9), 2045–2047.

American Diabetes Association. (2020). Prevention or Delay of Type 2 Diabetes: Standards of Medical Care in Diabetes—2020. Diabetes Care, 43(1), S32–S36.

Arigbede, O., Adeoye, I., Jarrett, O., & Yusuf, O. (2017). Prediabetes among Nigerian adolescents: A School-based study of the prevalence, risk factors and pattern of fasting blood glucose in Ibadan, Nigeria. International Journal of Diabetes in Developing Countries, 37(4), 437–445.

Basit, A., Fawwad, A., Qureshi, H., Shera, A. S., Ur Rehman Abro, M., Ahmed, K. I., Ahmed, K., Sabir Ali, S., Bilal, A., Butt, A., Devrajani, B. R., Hayder, I., Humayun, Y., Irshad, R., Khan, R. A., Khan, A., Khowaja, A. A., Khowaja, R., Masroor, Q., … Zafar, J. (2018). Prevalence of diabetes, pre-diabetes and associated risk factors: second National Diabetes Survey of Pakistan (NDSP), 2016–2017. BMJ Open, 8(8).

Brannick, B., & Dagogo-Jack, S. (2018). Prediabetes and Cardiovascular Disease: Pathophysiology and Interventions for Prevention and Risk Reduction. In Endocrinology and Metabolism Clinics of North America (Vol. 47, Issue 1, pp. 33–50). Elsevier Inc.

Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., Huikuri, H. V., Johansson, I., Juni, P., Lettino, M., Marx, N., Mellbin, L. G., Ostgren, C. J., Rocca, B., Roffi, M., … Chowdhury, T. A. (2020). 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. European Heart Journal, 41(2), 255–323.

Ely, E. K., Gruss, S. M., Luman, E. T., Gregg, E. W., Ali, M. K., Nhim, K., Rolka, D. B., & Albright, A. L. (2017). A National Effort to Prevent Type 2 Diabetes: Participant-Level Evaluation of CDC’s National Diabetes Prevention Program. Diabetes Care, 40(10), 1331–1341.

Fayh, A. P. T., Lopes, A. L., Fernandes, P. R., Reischak-Oliveira, A., & Friedman, R. (2013). Impact of Weight Loss With or Without Exercise on Abdominal Fat and Insulin Resistance in Obese Individuals: A Randomised Clinical Trial. British Journal of Nutrition, 110(3), 486–492.

Garnett, S. P., Baur, L. A., Noakes, M., Steinbeck, K., Woodhead, H. J., Burrell, S., Chisholm, K., Broderick, C. R., Parker, R., De, S., Shrinivasan, S., Hopley, L., Hendrie, G., Ambler, G. R., Kohn, M. R., & Cowell, C. T. (2010). Researching Effective Strategies to Improve Insulin Sensitivity in Children and Teenagers - RESIST. A Randomised Control Trial Investigating the Effects of Two Different Diets on Insulin Sensitivity in Young People with Insulin Resistance and/or Pre-Diabe. BMC Public Health, 10(575), 1–10.

Hamman, R. F., Wing, R. R., Edelstein, S. L., Lachin, J. M., Bray, G. A., Delahanty, L., Hoskin, M., Kriska, A. M., Mayer-Davis, E. J., Pi-Sunyer, X., Regensteiner, J., Venditti, B., & Wylie-Rosett, J. (2012). Effect of Weight Loss With Lifestyle Intervention on risk of Diabetes. Diabetes Care, 29(9), 2102–2107.

Heianza, Y., Hara, S., Arase, Y., Saito, K., Fujiwara, K., Tsuji, H., Kodama, S., Hsieh, S. D., Mori, Y., Shimano, H., Yamada, N., Kosaka, K., & Sone, H. (2011). HbA1c 5•7-6•4% and Impaired Fasting Plasma Glucose for Diagnosis of Prediabetes and Risk of Progression to Diabetes in Japan (TOPICS 3): A Longitudinal Cohort Study. The Lancet, 378(9786), 147–155.

Hostalek, U. (2019). Global Epidemiology of Prediabetes - Present and Future Perspectives. Clinical Diabetes and Endocrinology, 5(1), 1–5.

Kementerian Kesehatan RI. (2019). Laporan Nasional RISKESDAS 2018. Badan Penelitian dan Pengembangan Kesehatan.

Kerrison, G., Gillis, R. B., Jiwani, S. I., Alzahrani, Q., Kok, S., Harding, S. E., Shaw, I., & Adams, G. G. (2017). The Effectiveness of Lifestyle Adaptation for the Prevention of Prediabetes in Adults: A Systematic Review. Journal of Diabetes Research, 2017, 1–20.

Khokhar, A., & Chin, V. L. (2017). Metformin Use in Children and Adolescents with Prediabetes. Pediatric Clinics of North America, 64(6), 1341–53.

Knowler, W. C., Barrett-Connor, E., Fowler, S. E., Hamman, R. F., Lachin, J. M., Walker, E. A., & Nathan, D. M. (2002). Reduction in The Incidence of Type 2 Diabetes With Lifestyle Intervention or Metformin. The New England Journal Of Medicine, 346(6), 393–403.

Kosaka, K., Noda, M., & Kuzuya, T. (2005). Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males. Diabetes Research and Clinical Practice, 67(2), 152–162.

Kouvelioti R, Vagenas G, L.-E. S. (2014). Effects of Exercise and Diet on Weight Loss Maintenance in Overweight and Obese Adults: A Systematic Review. The Journal of Sports Medicine and Physical Fitness, 54(4), 456–474.

Kulzer, B., Hermanns, N., Gorges, D., Schwarz, P., & Haak, T. (2009). Prevention of Diabetes Self-Management Program (PREDIAS): Effects on Weight, Metabolic Risk Factors, and Behavioral Outcomes. Diabetes Care, 32(7), 1143–1146.

Meilawati, S. (2020). Studi Literatur Efek Modifikasi Gaya Hidup Secara Intensif Pada Prediabetes. Jurnal Ilmu Kedokteran Dan Kesehatan, 7(4), 579.

Rariden, C. (2018). Prediabetes: Early Identification and Management. Nurse Practitioner, 43(12), 35–40.

Rariden, C. (2019). Prediabetes: A Wake-up Call. Nursing, 49(4), 39–44.

Rentería-mexía, A., Vega-lópez, S., Olson, M. L., Swan, P. D., Lee, C. D., Williams, A. N., & Shaibi, G. Q. (2019). Effects of a Lifestyle Intervention on Markers of Cardiometabolic Risk and Oxidized Lipoproteins Among Obese Adolescents With Prediabetes. Public Health Nutrition, 22(4), 706–713.

Ramadhan, M. (2019). Patient Empowerment Dan Self-Management Pada Pasien Diabetes Mellitus Tipe 2. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2 SE-Articles).

Ronald T. Ackermann, Finch, E. A., Brizendine, E., Zhou, H., & Marrero, D. G. (2008). Translating the Diabetes Prevention Program into the Community The DEPLOY Pilot Study. American Journal Of Preventive Medicine, 35(4), 357–363.

Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., Shaw, J. E., Bright, D., & Williams, R. (2019). Global and Regional Diabetes Prevalence Estimates For 2019 and Projections For 2030 and 2045: Results From The International Diabetes Federation Diabetes Atlas, 9th Edition. Diabetes Research and Clinical Practice, 157, 1–10.

Safitri, N., Kusumaningrum, D., Hidayati, W., & Muin, M. (2020). Prediabetes and the Contributing Factors: A Study in Semarang Central Java. Jurnal Keperawatan Sudirman, 15(2), 39–48.

Sampson, M., Clark, A., Bachmann, M., Garner, N., Irvine, L., Howe, A., Greaves, C., Auckland, S., Smith, J., Turner, J., Rea, D., Rayman, G., Dhatariya, K., John, W. G., Barton, G., Usher, R., Ferns, C., & Pascale, M. (2020). Lifestyle Intervention with or without Lay Volunteers to Prevent Type 2 Diabetes in People with Impaired Fasting Glucose and/or Nondiabetic Hyperglycemia: A Randomized Clinical Trial. JAMA Internal Medicine, 181(2), 168–178.

Savoye, M., Caprio, S., Dziura, J., Camp, A., Germain, G., Summers, C., Li, F., Shaw, M., Nowicka, P., Kursawe, R., DePourcq, F., Kim, G., & Tamborlane, W. V. (2014). Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial. Diabetes Care, 37(2), 317–324.

Singhal, N., Misra, A., Shah, P., Gulati, S., Bhatt, S., Sharma, S., & Pandey, R. M. (2011). Impact of Intensive School-Based Nutrition Education and Lifestyle Interventions on Insulin Resistance, β-Cell Function, Disposition Index, and Subclinical Inflammation Among Asian Indian Adolescents: A Controlled Intervention Study. Metabolic Syndrome and Related Disorders, 9(2), 143–150.

Terathongkum, S., Wangpitipanit, S., Kraithaworn, P., & Vallibhakara, S. A. O. (2018). A Community-Based Lifestyle Modification for Prevention Diabetes in Pre-Diabetes: A Quasi-Experimental Study. Journal of the Medical Association of Thailand, 101(3), 297–304.

Thorpe, K. E., & Yang, Z. (2011). Enrolling People With Prediabetes Ages 60-64 in a Proven Weight Loss Program Could Save Medicare $7 Billion or More. Health Affairs, 30(9), 1673–1679.

Tuso, P. (2014). Prediabetes and Lifestyle Modification: Time to Prevent a Preventable Disease. The Permanent Journal, 18(3), 88–93.

Watson, C. S. (2017). Prediabetes: Screening, Diagnosis, and Intervention. Journal for Nurse Practitioners, 13(3), 216-221.e1.

Weiss, R., Santoro, N., Giannini, C., Galderisi, A., Umano, G. R., & Caprio, S. (2017). Prediabetes in Youths: Mechanisms and Biomarkers. The Lancet Child and Adolescent Health, 1(3), 240–248.

WHO. (2021). Diabetes. World Health Organization.

Zhuo, X., Zhang, P., Gregg, E. W., Barker, L., Hoerger, T. J., Pearson-Clarke, T., & Albright, A. (2012). A Nationwide Community-Based Lifestyle Program Could Delay Or Prevent Type 2 Diabetes Cases And Save $5.7 Billion In 25 Years. Health Affairs, 31(1), 50–60.

How to Cite
Fitriani, F., & Sanghati, S. (2021). Lifestyle Interventions on Prevention of Type 2 Diabetes Mellitus in Pre-Diabetes Patients. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 704-714.

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