Effect of Snakehead Fish Extract (Channa striata) and Metformin on Glycemic Control of Rats with Diabetes Mellitus Model

OK Yulizal, Ravinder Singh, Hendra Salim, Hendy Million

  • OK Yulizal Fakultas Kedokteran, Universitas Prima Indonesia
  • Ravinder Singh Universitas Prima Indonesia
  • Hendra Salim Universitas Prima Indonesia
  • Hendy Million Universitas Prima Indonesia
Keywords: Snakehead fish extract, diabetes mellitus, HbA1c

Abstract

Introduction; Diabetes mellitus (DM) is still a major problem where people with DM today range from 463 million adults aged 20-79 years (9.3%). Cork fish (Channa striata) is one of the natural ingredients containing albumin that is reviewed to have antioxidant activity in beta-pancreatic cells so it is believed to treat DM. Snakehead fish has some efficacy including; has antinociceptive activity, accelerates wound healing, and is an anti-inflammatory. Objective; To determine the effect of snakehead fish extract and metformin on glycemic control of male rats with diabetes mellitus. Methods; This study used an experimental method with a post-test-only control group design. Results; Based on the Kruskal Walis test, it showed (p < 0.05) meaning that there was an effect of EIG administration on reducing blood glucose levels in rats, and there was a reduction of HbA1c but not significant. Conclusion; The combination of snakehead fish extract 300mg/kg BW and metformin 45 mg/kg BW was superior in lowering blood glucose and HbA1c levels compared to single therapy with snakehead fish extract or metformin.

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Author Biographies

OK Yulizal, Fakultas Kedokteran, Universitas Prima Indonesia

Program Studi Pendidikan Dokter

Ravinder Singh, Universitas Prima Indonesia

Program Studi Pendidikan Dokter

Hendra Salim, Universitas Prima Indonesia

Program Studi Pendidikan Dokter

Hendy Million, Universitas Prima Indonesia

Program Studi Pendidikan Dokter

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Published
2021-12-31
How to Cite
Yulizal, O., Singh, R., Salim, H., & Million, H. (2021). Effect of Snakehead Fish Extract (Channa striata) and Metformin on Glycemic Control of Rats with Diabetes Mellitus Model. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 462-468. https://doi.org/10.35816/jiskh.v10i2.639
Section
Articles

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