Gastroprotective Effectiveness of Turmeric (Curcuma Domestica Val) Rhizome in Aspirin Induced Stomach
Shelvia Athala
Abstract
Background: In the case of peptic ulcer, it is found mainly intermittent lesions and is most often diagnosed in middle-aged to elderly adults, but these lesions may have appeared from a young age which often occurs due to the use of non-steroidal anti-inflammatory drugs (NSAIDs). -selective, such as aspirin. Turmeric can protect the gastric mucosa by increasing mucus secretion and has a vasodilator effect so that turmeric can increase the gastric mucosal defense. Objective: to determine the effect of turmeric rhizome extract on gastric damage. Methods: Using literature studies from both national and international journals by summarizing the discussion topics and comparing the results presented in each article. Result: The essential oil contained in turmeric is efficacious to regulate the release of stomach acid so that it is not excessive. Turmeric is also thought to have analgesic activity because it contains curcuminoids and essential oils. Curcumin has an effect on COX-2 (cyclooxygenase2), nitric oxide synthesis, and biomarkers of the inflammatory response that will increase the production of macrophage cells from TNF- so that inflammation is reduced. Conclusion: administration of turmeric extract can stabilize the pH of gastric acid so that it can increase the healing rate of gastric ulcers. So that the turmeric rhizome has a protective effect on the stomach
Downloads
References
Amrulloh, F. M., & Utami, N. (2016). Hubungan Konsumsi OAINS terhadap Gastritis The Relation of NSAID Consumption to Gastritis. 5, 18–21.
Atiq Himma. (2010). Pengaruh Ekstrak Rimpang Kunyit Kuning (Curcuma Domestica Val.) Dengan Pelarut Etanol Terhadap Pertumbuhan Bacillus Subtilis, Escherichia Coli, Salmonella Typhi, Dan Shigella Dysentriae. Skripsi.
Bjarnason, I., Scarpignato, C., Holmgren, E., Olszewski, M., Rainsford, K. D., & Lanas, A. (2018). Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs. Gastroenterology, 154(3), 500–514.
https://doi.org/https://doi.org/10.1053/j.gastro.2017.10.049
Botani, T., Klasifikasi, T., & Divisi, K. (2009). BAB I. 3–12.
Budianto, N. E. (2014). Ekstrak etanol kunyit (. 3, 48–56.
Cruccu, G., Sommer, C., Anand, P., Attal, N., Baron, R., Garcia-Larrea, L., Haanpaa, M., Jensen, T. S., Serra, J., & Treede, R. D. (2010). EFNS guidelines on neuropathic pain assessment: Revised 2009. European Journal of Neurology, 17(8), 1010–1018.
https://doi.org/10.1111/j.1468-1331.2010.02969.x
Fahrumnisa, A. (2019). Ekstrak Kunyit (Curcuma longa) sebagai Tatalaksana Sindrom Polikistik Ovarium. Jurnal Ilmiah Kesehatan Sandi Husada, 8(2 SE-Articles).
https://doi.org/10.35816/jiskh.v10i2.125
Fenda Adita. (2010). Pengaruh Pemberian Kunyit ( Curcuma D Omestica Val.) Terhadap Kerusakan Histologis Mukosa Gaster Mencit ( Mus M Usculus ) Yang Diinduksi Aspirin. In Fakultas Kedokteran Universitas Sebelas Maret Surakarta (Vol. 8, Issue 5).
Grawish, M. E., Zaher, A. R., Gaafar, A. I., & Nasif, W. A. (2010). Long-term effect of Spirulina platensis extract on DMBA-induced hamster buccal pouch carcinogenesis (immunohistochemical study). Medical Oncology, 27(1), 20–28.
https://doi.org/10.1007/s12032-008-9164-x
Hojo, M., Asahara, T., Nagahara, A., Takeda, T., Matsumoto, K., Ueyama, H., Matsumoto, K., Asaoka, D., Takahashi, T., Nomoto, K., Yamashiro, Y., & Watanabe, S. (2018). Gut Microbiota Composition Before and After Use of Proton Pump Inhibitors. Digestive Diseases and Sciences, 63(11), 2940–2949. https://doi.org/10.1007/s10620-018-5122-4
Hong, J., Bose, M., Ju, J., Ryu, J.-H., Chen, X., Sang, S., Lee, M.-J., & Yang, C. S. (2004). Modulation of arachidonic acid metabolism by curcumin and related β-diketone derivatives: effects on cytosolic phospholipase A 2 , cyclooxygenases and 5-lipoxygenase . Carcinogenesis, 25(9), 1671–1679. https://doi.org/10.1093/carcin/bgh165
Kusbiantoro, D. ∙ Y. P. (2018). Pemanfaatan kandungan metabolit sekunder pada tanaman kunyit dalam mendukung peningkatan pendapatan masyarakat Utilization of secondary metabolite in the turmeric plant to increase community income. 17(1), 544–549.
Muniroh, L., Martini, S., Nindya, T. S., & Solfaine, R. (2010). Minyak Atsiri Kunyit sebagai Anti Radang pada Penderit Gout Artritis Dengan Diet Tinggi Purin. Makara Seri Kesehatan, 14(2), 57–64.
Nabila Salwa Raehana. (2021). Efek Gastroprotektif pemberian Rimpang Kunyit (Curcuma domestica Val.) dari Ulkus Lambung yang diinduksi oleh NSAID. UJrnal Medika Hutama, 02(02), 439–447.
Pratiwi, A. (2020). Efek Gastroprotektor Madu Terhadap Penyembuhan Tukak Lambung. Jurnal Ilmiah Kesehatan Sandi Husada, 9(1 SE-Articles). https://doi.org/10.35816/jiskh.v11i1.340
Puteri, F. (2020). Effect of Curcumin on Turmeric ( Curcuma longa) as a Tretment for Stomach Cancer. Jurnal Ilmiah Kesehatan Sandi Husada, 9(2 SE-Articles).
https://doi.org/10.35816/jiskh.v12i2.426
Rahman, H., Sari, P. M., Maharini, I., & Septiana, B. A. (2020). Potensi Ekstrak Kering Belut (Monopterus albus) pada Pengobatan Tukak Lambung. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 17(1), 98.
https://doi.org/10.30595/pharmacy.v17i1.5727
Schellack, N. (2012). An overview of gastropathy induced by nonsteroidal anti-inflammatory drugs. SA Pharmaceutical Journal, 79(4), 12–18.
Septyarani, E. (2019). Potensi Buah Pare (Momordhica Charantia) Sebagai Agen Pengobatan Ulkus Peptikum. Jurnal Ilmiah Kesehatan Sandi Husada, 8(2 SE-Articles). https://doi.org/10.35816/jiskh.v10i2.154
Simbolon, S. B., Katar, Y., & Rusjdi, S. R. (2018). Efektivitas Kombinasi Ekstrak Kunyit (Curcuma Domestica Val) dan Madu Terhadap Ulkus Lambung Mencit BALB/c Akibat Pemberian Aspirin Secara Mikroskopis. Jurnal Kesehatan Andalas, 7(1), 26. https://doi.org/10.25077/jka.v7i1.776
Sutriyo, S. (2011). Formulasi Sediaan Granul Mukoadhesif Kombinasi Ekstrak Kulit Batang Mimba (Azadirachta indica A. Juss) dan Kunyit (Curcuma domestica val.). Pharmaceutical Sciences and Research, 8(2). https://doi.org/10.7454/psr.v8i2.3476
Tarigan, A. K. M., & Bayer, S. B. (2012). Temporal change analysis of public attitude, knowledge and acceptance of hydrogen vehicles in Greater Stavanger, 2006–2009. Renewable and Sustainable Energy Reviews, 16(8), 5535–5544.
https://doi.org/https://doi.org/10.1016/j.rser.2012.05.045
Thomas, D., Govindhan, S., Baiju, E. C., Padmavathi, G., Kunnumakkara, A. B., & Padikkala, J. (2015). Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress. Journal of Basic and Clinical Physiology and Pharmacology, 26(5), 485–490. https://doi.org/doi:10.1515/jbcpp-2014-0093
3.png){kind=logo}
