Effect of Irisin on Browning of White Fat

Natalia Danayati

  • Natalia Danayati Universitas Lampung
Keywords: Irisin, Brown Fat, White Fat


Background: Irisin is a new myokin that relates to physical activity that is associated with increased metabolic performance and is associated with browning of white adipose tissue. Irisin is of concern because of its potential as a therapeutic agent in the treatment of obesity, diabetes, and other related conditions. Method: Using literature study from scientific sources by summarizing publications and comparing the results presented. Results: Irisin, which is secreted from muscle, stimulates the expression of uncoupling protein 1 (UCP1) in adipocytes which causes browning of white adipose tissue via p38 mitogen-activated protein kinase (MAPK) and via extracellular-signal-regulated kinase (ERK). Conclusion: Irisin which is secreted by skeletal muscle will express UPC-1 in adipose tissue which will cause white adipose tissue to turn brown and increase the activity of thermogenesis.


Download data is not yet available.

Author Biography

Natalia Danayati, Universitas Lampung

Fakultas kedokteran


Arhire, L. I., Mihalache, L., & Covasa, M. (2019). Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome. Frontiers in Endocrinology, 10(August), 1–12. https://doi.org/10.3389/fendo.2019.00524

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., Kajimura, S., Zingaretti, M. C., Vind, B. F., Tu, H., Cinti, S., Højlund, K., Gygi, S. P., & Spiegelman, B. M. (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463–468. https://doi.org/10.1038/nature10777

Eckel, J. (2018). Skeletal Muscle: A Novel Secretory Organ. The Cellular Secretome and Organ Crosstalk, 65–90. https://doi.org/10.1016/B978-0-12-809518-8.00003-9

Grygiel-Górniak, B., & Puszczewicz, M. (2017). A review on irisin, a new protagonist that mediates muscle-adipose-bone-neuron connectivity. European Review for Medical and Pharmacological Sciences, 21(20), 4687–4693.


Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A., Ruppenthal, S., Kaestner, L., & Meyer, T. (2013). Irisin and exercise training in humans - Results from a randomized controlled training trial. BMC Medicine, 11(1), 1–8. https://doi.org/10.1186/1741-7015-11-235

Huh, J. Y., Panagiotous, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Echneider, B. E., & Mantzoros, C. S. (2013). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. 61(12), 1725–1738. https://doi.org/10.1016/j.metabol.2012.09.002

Karundeng, R., Wangko, S., & Kalangi, S. J. R. (2014). JARINGAN LEMAK PUTIH DAN JARINGAN LEMAK COKLAT Aspek histofisiologi. Jurnal Biomedik (Jbm), 6(3). https://doi.org/10.35790/jbm.6.3.2014.6328

Legård, G. E., & Pedersen, B. K. (2018). Muscle as an Endocrine Organ. Muscle and Exercise Physiology, 285–307. https://doi.org/10.1016/B978-0-12-814593-7.00013-X

Mai, S., Grugni, G., Mele, C., Vietti, R., Vigna, L., Sartorio, A., Aimaretti, G., Scacchi, M., & Marzullo, P. (2020). Irisin levels in genetic and essential obesity: clues for a potential dual role. Scientific Reports, 10(1), 1–9. https://doi.org/10.1038/s41598-020-57855-5

Marrano, N., Biondi, G., Borrelli, A., Cignarelli, A., Perrini, S., Laviola, L., Giorgino, F., & Natalicchio, A. (2021). Irisin and incretin hormones: Similarities, differences, and implications in type 2 diabetes and obesity. Biomolecules, 11(2), 1–23. https://doi.org/10.3390/biom11020286

Meiliana, A., & Wijaya, A. (2014). Brown and Beige Fat: Therapeutic Potential in Obesity. The Indonesian Biomedical Journal, 6(2), 65. https://doi.org/10.18585/inabj.v6i2.32

Mukhtar, D. (2013). Makrofag Pada Jaringan Adiposa Obes Sebagai Penanda Terjadinya Resistensi Insulin. Majalah Ilmiah Widya, 3(317), 30–31.


Munoz, I. Y. M., Del Socorro Camarillo Romero, E., & De Jesus Garduno Garcia, J. (2018). Irisin a novel metabolic biomarker: Present knowledge and future directions. International Journal of Endocrinology, 2018. https://doi.org/10.1155/2018/7816806

Ohtaki, H. (2016). Irisin. In Handbook of Hormones (Vol. 5). Elsevier Inc. https://doi.org/10.1016/b978-0-12-801028-0.00037-4

Paleva, R. (2019). Mekanisme Resistensi Insulin Terkait Obesitas. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 354–358. https://doi.org/10.35816/jiskh.v10i2.190

Panati, K., Suneetha, Y., & Narala, V. R. (2016). Irisin/FNDC5 - An updated review. European Review for Medical and Pharmacological Sciences, 20(4), 689–697. https://www.europeanreview.org/article/10350

Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M. F.-R., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017). Physiology and role of irisin in glucose homeostasis. Physiology & Behavior, 13(1), 324–337.


Rusdiansyah, A. H. (2019). Pengaruh Aktivitas Fisik Sedang Terhadap Nilai Mean Arterial Pressure (Map) Pada Mahasiswa Obesitas Grade II. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 340–345. https://doi.org/10.35816/jiskh.v10i2.161

Saputra, I., Esfandiari, F., Marhayuni, E., & Nur, M. (2020). Indeks Massa Tubuh dengan Kadar Hb-A1c pada Pasien Diabetes Melitus Tipe II. Jurnal Ilmiah Kesehatan Sandi Husada, 9(2), 597–603. https://doi.org/10.35816/jiskh.v12i2.360

Schumacher, M. A., Chinnam, N., Ohashi, T., Shah, R. S., & Erickson, H. P. (2013). The structure of Irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: Implications for receptor activation. Journal of Biological Chemistry, 288(47), 33738–33744. https://doi.org/10.1074/jbc.M113.516641

Syahid, Z. M. (2021). Faktor yang Berhubungan dengan Kepatuhan Pengobatan Diabetes Mellitus. Jurnal Ilmiah Kesehatan Sandi Husada, 10(1), 147–155. https://doi.org/10.35816/jiskh.v10i1.546

Tine Kartinah, N., Rosalyn Sianipar, I., Nafi’Ah, & Rabia, R. (2018). The Effects of Exercise Regimens on Irisin Levels in Obese Rats Model: Comparing High-Intensity Intermittent with Continuous Moderate-Intensity Training. BioMed Research International, 2018(2012). https://doi.org/10.1155/2018/4708287

Vaughan, R. A., Gannon, N. P., Barberena, M. A., Garcia-Smith, R., Bisoffi, M., Mermier, C. M., Conn, C. A., & Trujillo, K. A. (2014). Characterization of the metabolic effects of irisin on skeletal muscle in vitro. Diabetes, Obesity and Metabolism, 16(8), 711–718. https://doi.org/10.1111/dom.12268

Xin, C., Liu, J., Zhang, J., Zhu, D., Wang, H., Xiong, L., Lee, Y., Ye, J., Lian, K., Xu, C., Zhang, L., Wang, Q., Liu, Y., & Tao, L. (2016). Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway. International Journal of Obesity, 40(3), 443–451. https://doi.org/10.1038/ijo.2015.199

Zhang, Y., Xie, C., Wang, H., Foss, R. M., Clare, M., George, E. V., Li, S., Katz, A., Cheng, H., Ding, Y., Tang, D., Reeves, W. H., & Yang, L. J. (2016). Irisin exerts dual effects on browning and adipogenesis of human white adipocytes. American Journal of Physiology - Endocrinology and Metabolism, 311(2), E530–E541. https://doi.org/10.1152/ajpendo.00094.2016

How to Cite
Danayati, N. (2021). Effect of Irisin on Browning of White Fat. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 396-401. https://doi.org/10.35816/jiskh.v10i2.611

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.