Obstructive Sleep Apnea (OSA) and Its Association with Vitamin D Deficiency.

Dandy Fahsi Algifary

  • Dandy Fahsi Algifary Universitas Lampung
Keywords: Apnea–hypopnea index, Obstructive Sleep Apnoea, Vitamin D

Abstract

It is estimated that as much as 2-4% of the total middle-aged population suffer from sleep apnea, with a trend towards men compared to women. The long-term effects of Obstructive Sleep Apnea (OSA) include impaired cognitive function, insulin resistance, cardiovascular disease, and depression. Research on the relationship between vitamin D and OSA severity has become an important concern because vitamin D deficiency is also a common medical problem worldwide, and its prevalence is increasing with obesity, sedentary lifestyles, limited sun exposure, and aging. The purpose of this literature study was to determine the relationship between OSA and the presence of Vitamin D deficiency. The literature sources used in this literature study involved 17 libraries from 1 national journal and 16 international journals. Various studies have shown an association between vitamin D deficiency and OSA caused by complex pathogenetic mechanisms and influenced by several confounding factors. Patients with severe OSA are generally associated with vitamin D deficiency.

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Author Biography

Dandy Fahsi Algifary, Universitas Lampung

Fakultas Kedokteran

References

Archontogeorgis, K., Nena, E., Papanas, N., & Steiropoulos, P. (2018). The role of vitamin D in obstructive sleep apnoea syndrome. Breathe, 14(3), 206–215. https://doi.org/10.1183/20734735.000618

Barceló, A., Esquinas, C., Piérola, J., De La Peña, M., Sánchez-De-La-Torre, M., Montserrat, J. M., Marín, J. M., Duran, J., Arqué, M., Bauça, J. M., & Barbé, F. (2013). Vitamin d status and parathyroid hormone levels in patients with obstructive sleep apnea. Respiration, 86(4), 295–301. https://doi.org/10.1159/000342748

Bouloukaki, I., Tsiligianni, I., Mermigkis, C., Bonsignore, M. R., Markakis, M., Pataka, A., Steiropoulos, P., Ermidou, C., Alexaki, I., Tzanakis, N., & Schiza, S. (2020). Vitamin D deficiency in patients evaluated for obstructive sleep apnea: is it associated with disease severity? Sleep and Breathing. https://doi.org/10.1007/s11325-020-02142-w

Bozkurt NC, Cakal E, Sahin M, Ozkaya EC, Firat H, Delibasi T. The relation of serum 25-hydroxyvitamin-D levels with severity of obstructive sleep apnea and glucose metabolism abnormalities. Endocrine. 2012;41(3):518-525. doi:10.1007/s12020-012-9595-1

Bromińska, B., Ruchała, M., Cyrańska-Chyrek, E., Kuźnar-Kamińska, B., Kostrzewska, M., & Batura-Gabryel, H. (2017). State of the art paper Obstructive sleep apnea and hormones – a novel insight. Arch Med Sci, 13(4), 875–884. https://doi.org/10.5114/aoms.2016.61499

Gharibeh, T., & Mehra, R. (2010). Obstructive sleep apnea syndrome: Natural history, diagnosis, and emerging treatment options. Nature and Science of Sleep, 2, 233–255. https://doi.org/10.2147/NSS.S6844

Goswami, U., Ensrud, K. E., Paudel, M. L., Redline, S., Schernhammer, E. S., Shikany, J. M., Stone, K. L., & Kunisaki, K. M. (2016). Vitamin D concentrations and obstructive sleep apnea in a multicenter cohort of older males. Annals of the American Thoracic Society, 13(5), 712–718. https://doi.org/10.1513/AnnalsATS.201507-440OC

Hukins, C. A. (2006). Obstructive sleep apnea - Management update. Neuropsychiatric Disease and Treatment, 2(3), 309–326. https://doi.org/10.2147/nedt.2006.2.3.309

Kadarullah, O. Annisa, Y. (2016). Pengaruh Obstructive Sleep Apnea ( OSA ) Terhadap Terjadinya Hipertensi Di Poli Saraf RSUD Prof. Dr. Margono Soekarjo. XIII(2), 11–21.

Kerley, C. P., Hutchinson, K., Bolger, K., McGowan, A., Faul, J., & Cormican, L. (2016). Serum Vitamin D is significantly inversely associated with disease severity in Caucasian adults with obstructive sleep apnea syndrome. Sleep, 39(2), 293–300. https://doi.org/10.5665/sleep.5430

Kheirandish-Gozal L, Peris E, Gozal D. Vitamin D levels and obstructive sleep apnoea in children. Sleep Med. 2014;15(4):459-463. doi:10.1016/j.sleep.2013.12.009

Kueider, A. M., Tanaka, T., An, Y., Kitner-Triolo, M. H., Palchamy, E., Ferrucci, L., & Thambisetty, M. (2016). State- and trait-dependent associations of vitamin-D with brain function during aging. Neurobiology of Aging, 39, 38–45. https://doi.org/10.1016/j.neurobiolaging.2015.11.002

Ma, D., Zheng, X., Dong, L., Zheng, C., Chen, Y., Chen, Z., Lin, M., Li, X., Li, Z., & Liu, C. (2020). The relationship of serum 25-hydroxyvitamin-d level with severity of obstructive sleep apnea in patients with type 2 diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, 1391–1398. https://doi.org/10.2147/DMSO.S250694

Mete, T., Yalcin, Y., Berker, D., Ciftci, B., Guven, S. F., Topaloglu, O., Yavuz, H. C., & Guler, S. (2013). Obstructive sleep apnea syndrome and its association with vitamin D deficiency. Journal of Endocrinological Investigation, 36(9), 681–685. https://doi.org/10.3275/8923

Neighbors CLP, Noller MW, Song SA, et al. Vitamin D and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med. 2018;43:100-108. doi:10.1016/j.sleep.2017.10.016

Rejnmark, L. (2011). Effects of vitamin D on muscle function and performance: A review of evidence from randomized controlled trials. Therapeutic Advances in Chronic Disease, 2(1), 25–37. https://doi.org/10.1177/2040622310381934

Siachpazidou, D. I., Kotsiou, O. S., Stavrou, V., Pastaka, C., Gogou, E., Kechagia, M., Varsamas, C., Economou, N. T., Zouridis, S., Patrikioy, E., Seitanidis, G., Pinaka, M., Sistou, A., Hatzoglou, C., & Gourgoulianis, K. I. (2020). Serum vitamin D levels in patients with obstructive sleep apnea syndrome and level changes after continuous positive airway pressure therapy. Sleep and Breathing. https://doi.org/10.1007/s11325-020-02146-6

Published
2020-12-31
How to Cite
Algifary, D. (2020). Obstructive Sleep Apnea (OSA) and Its Association with Vitamin D Deficiency. Jurnal Ilmiah Kesehatan Sandi Husada, 9(2), 916-921. https://doi.org/10.35816/jiskh.v12i2.432

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