Efek Gastroprotektor Madu Terhadap Penyembuhan Tukak Lambung
Anisa Dian Pratiwi
Abstract
Background: One of the diseases that many people experience are gastrointestinal disorders, one of which is peptic ulcer, the excessive secretion of gastric acid (HCL) and pepsin by the gastric mucosa. The incidence of peptic ulcers is common due to Helicobacter pylori infection. Treatment and prevention of the diseases using traditional medicines are widely used, one of which is honey. Honey has general content consisting of glucose, fructose, sucrose, water, and number of amino acid, vitamins, minerals that are useful in the process of wound healing such as anti-inflammatory, antibacterial, antioxidant, and accelerate wound healing activities. Objective : To know the gastroprotective effect of honey on healing peptic ulcers. Methods : Using literature studies from national and international journals by summarizing the topic of discussion and comparing the results presented in the article. Results : Honey has gastroprotective effect with hyperosmolar characteristic due to its high concentration of sugar and low concentration of water which causes increase in osmotic pressure and water inside the microbial cells to come out so resulting in plasmolysis. Honey also has hygroscopic characteristic due to its low pH which allows microbes to dehydrate and doesn’t allow them to grow. High concentration of sugar in honey has osmotic characteristic that can inhibit bacterial growth. Conclusion: Honey has gastroprotective effect to help the healing process of peptic ulcers because it has potential as anti-inflammatory, antioxidant, antibacterial, and stimulates wound healing.
Downloads
References
Al-waili, N. S., Salom, K., & Al-ghamdi, A. A. (2011). Honey for Wound Healing , Ulcers , and Burns ; Data Supporting Its Use in Clinical Practice, 766–787. https://doi.org/10.1100/tsw.2011.78
Amrulloh, F. M., & Utami, N. (2016). Hubungan Konsumsi OAINS terhadap Gastritis The Relation of NSAID Consumption to Gastritis, 5, 18–21.
Evahelda, Pratama, F., Malahayati, N., & Santoso, B. (2017). Sifat Fisik dan Kimia Madu dari Nektar Pohon Karet di Kabupaten Bangka Tengah , Indonesia Physical and Chemical Characteristics of Honey from Rubber Tree Nectar in Central Bangka Regency , Indonesia, 37(4), 363–368.
Fazalda, A., Quraisiah, A., Fahami, M., & Azlina, N. (2018). Antiulcer Effect of Honey in Nonsteroidal Anti-Inflammatory Drugs Induced Gastric Ulcer Model in Rats : A Systematic Review, 2018. https://doi.org/10.1155/2018/7515692
Fitrianingsih, S. P., & Choesrina, R. (2011). Uji Aktivitas Madu Sebagai Antitukak Lambung Terhadap Tikus Putih Galur Wistar, 9–16.
Gunawan, N. A. (2017). Madu : Efektivitasnya untuk Perawatan Luka, 44(2), 138–142.
Haqiqi, F. N. (2015). Efek Pemberian Madu Hutan terhadap Mukosa Gaster yang Diinduksi Ibuprofen Suspensi The Effect Of Honey For Gastric Mucose that Induced by Ibuprofen Suspension, 4(November), 127–132.
Muhartono, DN, F., & GN, K. (2013). Fakultas Kedokteran Universitas Lampung Fakultas Kedokteran Universitas Lampung, 1(2), 52–62.
Nzeako, B. C., & Al-namaani, F. (2006). The Antibacterial Activity of Honey on Helicobacter Pylori, 6(2).
Purnamasari, L. (2017). Faktor Risiko , Klasifikasi , dan Terapi Sindrom Dispepsia, 44(12), 870–873.
Santika, N. Y., Desnita, R., Yuswar, M. A., Studi, P., Fakultas, F., Universitas, K., … Obat, J. (2019). Evaluasi Penggunaan Obat Tukak Peptik pada Pasien Tukak Peptik di Instalasi Rawat Inap RSUD Sultan Syarif Mohamad Alkadrie Pontianak, 15(1), 1–15.
Schellack, N., Schellack, G., Sandt, N. Van Der, & Masuku, B. (2017). Gastric pain, (January 2015).
Suhatri, Hansen, & Hengky. (2014). Analisis Terapi Pada Pasien Tukak Peptikdi SMF. Jurnal B-Dent, 1(1), 56–63.
Standar Nasional Indonesia (SNI) nomor 01-3545-2004 tahun 2004 tentang Madu.
Suprijono, A., Trisnadi, S., & Negara Perwira, H. (2011). Pengaruh Pemberian Madu terhadap Gambaran Histopatologi Lambung Studi pada Tikus Putih Jantan Galur Wistar yang Diinduksi The Effect of Honey Administration on Gastrohistopathological Image, 41–47.