Pengaruh Madu Ceiba Pentandra Terhadap Kadar LDL Tikus Rattus Norvegicus Yang Diberi Diet Tinggi Lemak
Hetti Rusmini, Devita Febriani Putri, Hidayat, Dhani Risandy
Abstract
Background: Hypercholesterolemia is a condition of the body that has increased cholesterol levels above the normal threshold (<200 mg/dL). Hypercholesterolemia can occur because of lifestyle that not healthy, ranging from diet is not balanced to the lack of sporting activity. Hypercholesterolemia is the main risk factor for atherosclerosis which is the increase in Low Density Lipoprotein (LDL). Methodology: The type of research used is purely experimental using a pre and post test design with group design. The population used in this study were 25 male Wistar strain rats which were divided into 5 groups. Sampling using the method of total sampling. Data were analyzed by Paired T-test and Anova. Research Results: In this study, from the 5 sample groups obtained the results of the analysis Paired T-Test, obtained a significant increase (p <0.05) of LDL levels after giving a high-fat diet in the negative group (p = 0.025), treatment group 2 (p = 0.001), and treatment group 3 (p= 0.001). In the treatment after the administration of honey, there was a significant decrease (p <0.05) of LDL levels in 2 groups, namely in the treatment group 2 (p = 0.026), and the treatment group 3 (p = 0.092). With Anova analysis, a significant difference was found in the treatment after the administration of a high-fat diet and after the provision of honey honey with the same p value, namely p = 0.001 (P <0.05). Conclusion: There are differences that influence the administration of honey honey on LDL levels in wistar strain rats given a high-fat diet.
Downloads
References
Munstedt, K., Hoffman, S, Hauenschild., Bulte, M., Georgi, V.R., Hackethal, A. (2009). Effect of Honey On Serum Cholesterol and Lipid Values. J Med Food 12 (3): 624-628.
Musunuru, K. (2010). Atherogenic dyslipidemia: cardiovascular risk dietary intervention. Lipids, 45(10), 907–14.
Cheng, C. P., Wu, K. L., Mai, C. C., Yang, C. T. C. K. C. T., Hsu, Y. S., Yan, B. H. B. H., Wüthrich, R.,
Abou Ziki, J. D., Paul, L., Korah, L. V., Sarkar, B. R., Doloi, B. N., Bhattacharyya, B.,
Zhang, Z., Huang, L., Jiang, Y. Y., Liu, G., Nie, X., Lu, H., … Little, A. D. (2018). No Title. International Journal of Machine Tools and Manufacture, 5(1), 86–96. https://doi.org/10.1016/j.ijmachtools.2009.09.004
Dedullah, R. F., Malonda, N. S. H., & Joseph, W. B. S. (2015). Hubungan antara faktor risiko hipertensi dengan kejadian hipertensi pada masyarakat di Kelurahan Motoboi Kecil Kecamatan Kotamobagu Selatan Kota Kotamobagu. Jurnal Kesmas, 4(2), 111–118.
Ekananda, N. A. (2015). [Artikel Review] Bay Leaf in Dyslipidemia Therapy. Dyslipidemia Therapy J MAJORITY |, 4, 64.
Gallmann, P. (2007). Minerals in honey: environmental, geographical and botanical aspects. Journal of Apicultural Research, August 2016, 269–275. https://doi.org/10.3896/ibra.1.46.4.11
Manalu, W., Suprayogi, A., Astuti, D. A., Anatomi, D., Hewan, F. K., Pertanian, I., Biologi, P. S., Pendidikan, F., Pengetahuan, I., Indonesia, U. P., Ilmu, D., Ternak, P., & Peternakan, F. (2013). Perbaikan Parameter Lipid Darah Mencit Hiperkolesterolemia dengan Suplemen Pangan Bekatul Improvement of Blood Lipid Parameters of Hypercholesterolemic Mice by Supplementation of Rice Bran. 45(1), 1–9.
Penelitian, A. (2014). Artikel Penelitian Pengaruh Bawang Putih (Allium Sativum) Terhadap Pencegahan Hiperkolesterolemia Pada Tikus The Effect Of Garlic (Allium Sativum ) On Prevention Of. 13(1), 9–16.
Rahma, S., Natsir, R., Kabo, P., Keperawatan, I., Gorontalo, U. N., Biokimia, B., Kedokteran, F., Hasanuddin, U., Kardiologi, B., Kedokteran, F., Hasanuddin, U., Dorsata, M., & Trigona, M. (2014). 1 , 2 , 3. 4(4), 377–384.
Tsalissavrina, I., Wahono, D., & Handayani, D. (2006). With High-Fat Diet Toward Triglyceride and Hdl Level in Blood. Pengaruh Pemberian Diet Tinggi Karbohidrat Dibandingkan Diet Tinggi Lemak Terhadap Kadar Trigliserida Dan Hdl
Darah Pada Rattus Novergicus Galur Wistar, 22(2), 80–89. https://jkb.ub.ac.id/index.php/jkb/article/viewFile/229/220
Welinsa, F., Asni, E., Malik, Z., & Ismawati. (2014). Histopatologi Aorta Torasika Rattus Novergicus Strain Wistar Jantan Setelah 8 Minggu Pemberian Diet Aterogenik. Jom FK, 2(1), 1–11. https://doi.org/10.1017/CBO9781107415324.004
3.png){kind=logo}
