Hubungan Antara Kadar Feritin Dengan Kreatinin Serum Pada Anak Thalasemia Mayor
Muhammad Asih Pambudi
Background : Patients with thalassemia that underwent routine blood transfusion are developing iron overload. In the state of excess iron, ferritin levelS increase. When iron storage capacity has been depleted, free iron will cause tissue damage. One of that damaged organ is the kidney. One parameter used to know the function of kidney is GFR (Glomerular Filtration Rate). A sample way to estimate GFR is serum creatinine. Increased 1-2 mg/dL of creatinine serum showed a decrease in ±50% of GFR. Objective: To determine the correlation between ferritin levels and serum creatinine in Thalassemia Major children at Abdul Moeloek hospital in Lampung Province in 2019. Research Method: This research is analytic descriptive with a cross-sectional approach. The sampling technique used was purposive sampling using secondary data from the results of medical records diagnosed with thalassemia major at Abdul Moeloe Hospital, and analyzed on a univariate basis to determine the frequency and bivariate distribution using the chi-square test. Results: The statistical test results obtained p-value of 0.028, it can be concluded that there is a correlation between ferritin levels with serum creatinine in children with Thalassemia major . The results of the analysis also obtained an OR value of 3.88 (95% CI 1.29-11.59 ) which means that respondents who had ferritin levels were at risk (≥ = 1000) 3.88 times greater had high creatinine levels compared to those who had levels ferritin is not at risk (≤1000). Conclusion: There is a correlation between ferritin levels with serum creatinine in Thalassemia B Major children at Abdul Moeloek Hospital in Lampung Province in 2019.
Doddamani, P., Suma, M.N., Ravi, A. Prashant, P. Vishwanath, dan N. C. . (2012). Importance of Assessment of Microalbuminuria in ß Thalassemia Major Patients. International Journal of Health and Allied Sciences, 1(4), 235–238.
Fibach, E. dan E. A. R. (20017). Pathophysiology and Treatment of Patients with Beta-Thalassemia. An Update. F1000Research, 6(2156), 1–12.
Forget, B. G. dan H. F. B. (2013). Classification of the Disorders of Hemoglobin. Cold Spring Harbor Perspective in Medicine, 3, 1–12.
Kiswari, R. (2014). Hematologi dan Transfusi. Jakarta: Erlangga.
Knovich, M. A., J. A. Storey, L. G. Coffman, dan S. V. T. (2009). Ferritin for the Clinician. Blood Review, 23(3), 95–104.
Mohkam, M., Karimi, A., Gharib, A., Daneshmand, H., Khatami, A., Ghojevand, N., & Sharifian, M. (2007). Ceftriaxone associated nephrolithiasis: a prospective study in 284 children. Pediatric Nephrology, 22(5), 690–694.
Muncie, H. L., dan J. S. C. (2019). Alpha and Beta Thalassemia. American Family Physicians, 80(4), 339–344.
Musallam, K.M., dan A. T. T. (2012). Mechanisms of Renal Disease in ßThalassemia. Journal of the American Society of Nephrology, 23, 1299–1302.
Quinn, C. T., V. L. Johnson, H. Y. Kim, F. Trachtenberg, M. G. Vogiatzi, J. L.Kwiatkowski, E. J. Neufeld, E. Fung, N. Oliveri, M. Kirby, dan P. J. G. (2011). Renal Dysfunction in Patients with Thalassemia. Br J Haematol., 153(1), 111–117.
Serruys, P. W., Ormiston, J. A., Onuma, Y., Regar, E., Gonzalo, N., Garcia-Garcia, H. M., … Miquel-Hébert, K. (2009). A bioabsorbable everolimus-eluting coronary stent system (ABSORB): 2-year outcomes and results from multiple imaging methods. The Lancet, 373(9667), 897–910.
Utami, E. D. R. (2013). Hubungan antara kadar feritin dengan kreatinin serum pada pasien thalassemia di rsud dr. Moewardi.
Vidyarni, K. E., Shodikin, M. A., & Riyanti, R. (2017). Hubungan antara Kadar Feritin dengan Kadar BUN-Kreatinin pada Pasien Talasemia Beta Mayor di RSD dr. Soebandi Jember (The Correlation between Ferritin Levels and BUN-Creatinine Levels of Major Beta Thalassemia Patients at dr. Soebandi Hospital Jember). Pustaka Kesehatan, 5(3), 525–530.
Wangsa-Wirawan, N. D., & Linsenmeier, R. A. (2003). Retinal oxygen: fundamental and clinical aspects. Archives of Ophthalmology, 121(4), 547–557.
Copyright (c) 2020 Jurnal Ilmiah Kesehatan Sandi Husada
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.