Derajat Toksisitas Trombosit pada Penderita Kanker Kolorektal yang Mendapat Kemoterapi CapeOX
Yusmaidi, Rakhmi Rafie, Muhammad Nur, Bilqis Nabilah
Abstract
Colorectal cancer treatment one of which is chemotherapy. One of the regimens/chemotherapy medicine is CapeOX (Capecitabine + Oxaliplatin). The use of oxaliplatin which is platinum-based chemotherapy has side effects in the form of hematological toxicity (myelosuppression) one of which is platelet count. Thrombocytopenia is a platelet count of less than 100,000 / mm3this is one of the hematological toxicity that can be found in colorectal cancer patients who received chemotherapy. Research Objective: The purpose of this study was to determine the difference average of platelet levels and pre and post-chemotherapy CapeOX and the form of the degree of platelet toxicity in colorectal cancer patients receiving CapeOX chemotherapy.Method: This study is a historical (retrospective) cohort. The sample of this study was 70 patients obtained from a consecutive sampling calculation. Data analysis using Paired T-Test.Results: The age of colorectal cancer patients ranged from 18 to 73 years, with the highest frequency of 56-65 (38.6%), comparison of female 34 (48.6%) and male 36 (51.4%). The most widely used type of surgery was a Low Anterior Resection of 40 (57.1%). In this study, the highest decrease in platelet levels occurred in the sixth series of 54.186/mm3 with a standard deviation of 16.127/mm3. There was a decrease in average platelet levels highest occurred in the sixth cycle of 54,186 / mm3 with a standard deviation of 16,127 / mm3, and obtained first-degree platelets) toxicity in the 5th and 6th cycles of 3 (4.3%) and 18 (25.7) and who experienced second degree in the 5th and 6th cycles of 1 (1.4%) and 10 (14.3%).
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References
Abdullah, M., Sudoyo, A. W., Utomo, A. R., Fauzi, A., & Rani, A. A. (2012). Molecular profile of colorectal cancer in Indonesia: is there another pathway?. Gastroenterology and Hepatology from bed to the bench, 5(2), 71.
American Cancer Society (2011) Information and Resources about Cancer: Colorectal Cancer. Diakses pada September 2019. Sumber, https://www.cancer.org/
Smeltzer, S. C., & Bare, B. G. (2001). Buku Ajar Keperawatan Medikal-Bedah, Vol. 3. EGC.
American Cancer Society (2014) Information and Resources about for Cancer: Colorectal Cancer. Diakses pada September 2019. Sumber, https://www.cancer.org/
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018:
GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 68(6), 394-424.
Harahap, ARN. Faktor risiko yang berhubungan dengan kejadian kanker kolorektal di RSUD dr. H. Abdul Moeloek Bandar Lampung Tahun 2013-2016. [Tugas Akhir]. Bandar Lampung: Universitas Lampung; 2019.
Harvey, R. A., & Champe, P. C. (2013). Farmakologi ulasan bergambar. Jakarta: EGC.
Huq F, Yu JQ. Beale P. Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy. Studies on New Platinum Compound. Totowa: Humana Press; 2009.
Kelompok Kerja Kanker Kolorektal Indonesia (2014). Pengelolaan Karsinoma Kolorektal, Suatu Panduan Klinis Nasional. Sumber: http://download.ikabdi.org/Panduan_KKR_(radioterapi_updated).doc
Kementerian Kesehatan Republik Indonesia. (2018) Keputusan Menteri Kesehatab Republik Indonesia, Pedoman Nasional Pelayanan Kedokteran Tata Laksana Kanker Kolorektal. Jakarta:Kementerian Kesehatan
Hamas Izzaty, A. (2015). Hubungan Antara Faktor Usia Dengan Kejadian Kanker Kolorektal Di Rsud Moewardi Surakarta Tahun 2010-2013 (Doctoral dissertation, Universitas Muhammadiyah Surakarta)
Lao, V. V., & Grady, W. M. (2011). Epigenetics and colorectal cancer. Nature Reviews Gastroenterology & hepatology, 8(12), 686.Taleghani BM, Fontana S, Meyer O, Ahrens N, Novak U, Borner MM, et al. Oxaliplatin induced immune pancytopenia. Transfusion. 2005;45(5):704–8.
Lin, J. H., Zhang, S. M., Rexrode, K. M., Manson, J. E., Chan, A. T., Wu, K., ... & Buring, J. E. (2013). Association between sex hormones and colorectal cancer risk in men and women. Clinical Gastroenterology and Hepatology, 11(4), 419-424.
Liu, L. G., Yan, X. B., Shan, Z. Z., Yan, L. L., Jiang, C. Y., Zhou, J., ... & Jin, Z. M. (2017). Anorectal functional outcome following laparoscopic low anterior resection for rectal cancer. Molecular and clinical oncology, 6(4), 613-621.
Sakai, E., Nakajima, A., & Kaneda, A. (2014). Accumulation of aberrant DNA methylation during colorectal cancer development. World Journal of Gastroenterology: WJG, 20(4), 978.
Sugiarti, M. (2017). Pengaruh Khemoterapi Terhadap Jumlah Trombosit Pasien Penderita Kanker di RS Abdul Moeloek Provinsi Lampung. Jurnal Analis Kesehatan, 4(2), 450-455.
Wahidin, M., Noviani, R., Hermawan, S., Andriani, V., Ardian, A., & Djarir, H. (2012). Population-based cancer registration in Indonesia. Asian Pacific Journal of Cancer Prevention, 13(4), 1709-1710.
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