Derajat Toksisitas Trombosit pada Penderita Kanker Kolorektal yang Mendapat Kemoterapi CapeOX

Yusmaidi, Rakhmi Rafie, Muhammad Nur, Bilqis Nabilah

  • Yusmaidi Yusmaidi Rumah Sakit Abdul Moeloek
  • Rakhmi Rafie Universitas Malahayati
  • Muhammad Nur Rumah Sakit Pringsewu
  • Bilqis Nabilah Universitas Malahayati
Keywords: Kanker kolorektal, Kemoterapi, Trombosit

Abstract

Colorectal cancer treatment one of which is chemotherapy. One of the regimens/chemotherapy medicine is CapeOX (Capecitabine + Oxaliplatin). The use of oxaliplatin which is platinum-based chemotherapy has side effects in the form of hematological toxicity (myelosuppression) one of which is platelet count. Thrombocytopenia is a platelet count of less than 100,000 / mm3this is one of the hematological toxicity that can be found in colorectal cancer patients who received chemotherapy. Research Objective: The purpose of this study was to determine the difference average of platelet levels and pre and post-chemotherapy CapeOX and the form of the degree of platelet toxicity in colorectal cancer patients receiving CapeOX chemotherapy.Method: This study is a historical (retrospective) cohort. The sample of this study was 70 patients obtained from a consecutive sampling calculation. Data analysis using Paired T-Test.Results: The age of colorectal cancer patients ranged from 18 to 73 years, with the highest frequency of 56-65 (38.6%), comparison of female 34 (48.6%) and male 36 (51.4%). The most widely used type of surgery was a Low Anterior Resection of 40 (57.1%). In this study, the highest decrease in platelet levels occurred in the sixth series of 54.186/mm3 with a standard deviation of 16.127/mm3. There was a decrease in average platelet levels highest occurred in the sixth cycle of 54,186 / mm3 with a standard deviation of 16,127 / mm3, and obtained first-degree platelets) toxicity in the 5th and 6th cycles of 3 (4.3%) and 18 (25.7) and who experienced second degree in the 5th and 6th cycles of 1 (1.4%) and 10 (14.3%).

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Author Biographies

Yusmaidi Yusmaidi, Rumah Sakit Abdul Moeloek

Departemen Bedah Digestif

Rakhmi Rafie, Universitas Malahayati

Departemen Anatomi Fakultas Kedokteran

Muhammad Nur, Rumah Sakit Pringsewu

Departemen Patologi Klinik

Bilqis Nabilah, Universitas Malahayati

Program Pendidikan Dokter Fakultas Kedokteran

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Published
2020-06-30
How to Cite
Yusmaidi, Y., Rafie, R., Nur, M., & Nabilah, B. (2020). Derajat Toksisitas Trombosit pada Penderita Kanker Kolorektal yang Mendapat Kemoterapi CapeOX. Jurnal Ilmiah Kesehatan Sandi Husada, 11(1), 313-320. https://doi.org/10.35816/jiskh.v11i1.281
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Articles