Hubungan Kadar Feritin Serum dengan Kadar Enzim SGOT dan SGPT pada Pasien Thalasemia β Mayor

Rita Agustina, Zulhafis Mandala, Ressy Nirmala Indah

  • Rita Agustina Universitas Malahayati
  • Zulhafis Mandala Universitas Malahayati
  • Ressy Nirmala Indah Universitas Malahayati
Keywords: Ferritin, SGOT and SGPT, Thalassemia.

Abstract

Thalassemia is a genetic blood disorder that can cause hemolysis in hemoglobin. So the patient must get a transfusion for life. The transfusion is done continuously, this is what causes patients with thalassemia β major to have iron buildup in their body. So the levels of Ferritin, SGOT, and SGPT enzymes can be increased in patients with β major thalassemia. This study aims to determine the relationship between serum ferritin with SGOT and SGPT enzymes in thalassemia β major patients. This research uses an analytic method with a cross-sectional approach. The subjects in this study were 60 samples. The instrument used was the patient's medical record data. Statistical analysis using the Chi-Square test showed a p-value 0.005 (p-value <0.05) for serum ferritin with SGOT. And for serum ferritin with SGPT enzymes, p-value 0.004 (p-value <0.05), it means that there is a relationship between serum ferritin and SGOT and SGPT enzymes. There is a correlation between serum ferritin with SGOT and SGPT enzymes in β major thalassemia patients at Abdul Moeloek Hospital Bandar Lampung.

Downloads

Download data is not yet available.

Author Biographies

Rita Agustina, Universitas Malahayati

Dosen Fakultas Kedokteran

Zulhafis Mandala, Universitas Malahayati

Depatemen Biokimia Fakultas Kedokteran

Ressy Nirmala Indah, Universitas Malahayati

Program Studi Kedokteran Fakultas Kedokteran

References

Alyumnah, P., Ghozali, M., & Dalimonethe, N.(2015). Skrining Thalasemia Beta Minor pada Siswa SMA di Jatinangor Suspected Beta Thalasemia Minor Screening in Jatinangor HighSchool Student, 1, 133-138

Hoffbrand, A.V., Moss, P.A.H.(2011). Kapita Selekta Hematologi. Edisi 6. Jakarta : EGC.

Hidayah, F. 2016. Gambaran penderita thalassemia yang di rawat di RSUD Dr. H. Abdoel Moeoek Kota Bandar Lampung Tahun 2010-2015. Skripsi. Bandar Lampung Universitas Malahayati.

Ikram, N, dkk.(2014). Feritin Levels in Patient of Beta Thalasemia Major. Int J Pathol. Singapore.

Katzung, Bertram G. (2010). Farmakologi Dasar dan Klinik. Edisi 10. Jakarta. EGC.

Nuari,A., Tjiptaningrum, T., Ristyaningrum, P., Basuki, W. (2016). Hubungan Kadar Feritin Serum dengan Aktivitas Enzim AST, ALT, dan Status Gizi pada Anak Talasemia β Mayor. Fakultas Kedokteran Universitas Lampung. Vol. 3, No. 1.

Pohan, A., Purwaningsih,E., & Dwijayanti,A.(2013). Efek Kelasi Etanol Daun Mangifera foetida pada Feritin Serum Penderita Thalasemia di RS Cipto Mangunkusumo, 1(1),46.

Prabandari, VL. 2014. Hubungan Antara Kadar Feritin dengan Kadar AST dan ALT.Surakarta : UNS.

Rosida, Azma.(2016). Pemeriksaan Labolatorium Penyakit Hati. Berkala Kedokteran. Banjarmasin : Fakultas Kedokteran Universitas Lambung Maruat. 12(1):123-131.

Sudoyo, W,A., Setiyadi, B., Alwi,I., Simadibrata,M,K., Setiyadi, S.(2006). Buku Ajar Ilmu Penyakit Dalam. Edisi VI. Jilid I. Jakarta Pusat Penerbitan Departemen Ilmu Penyakit dalam FK. Universitas Indonesia

Tahir, H., Shahid, S. A., & Mahmood, K. T. Complication in Thalassemia Patients Receiving Blood Transfusion. J Biomed Sci and Res. Vol.3, No. 1, 339-346

Thalassemia International Federation (TIF), 2008. Guidelines for the Clinical Management of Thalasemia :http://www.thalassemia.org.cy. Pada tanggal 14 Maret 2017

Word Health Organization (WHO), 2006. Control Of Genetic Disease di ambil dari :http://apps.who.int/gb/ebwh/pdf_files/EB116/B116_3-en.pdf.pada tanggal 14 maret 2017

Published
2020-06-30
How to Cite
Agustina, R., Mandala, Z., & Indah, R. (2020). Hubungan Kadar Feritin Serum dengan Kadar Enzim SGOT dan SGPT pada Pasien Thalasemia β Mayor. Jurnal Ilmiah Kesehatan Sandi Husada, 11(1), 252-257. https://doi.org/10.35816/jiskh.v11i1.258
Section
Articles