Potensi Cengkeh (Syzigium Aromaticum) sebagai Antibakteri Methicillin Resistant Staphylococcus Aureus (MRSA)

Panggih Daru Panuluh

  • Panggih Daru Panuluh Universitas Lampung
Keywords: antibiotic, clove, Staphylococcus aureus, Methicillin Resistant Staphylococcus aureus (MRSA)


The threat of disease from bacterial strains that are pathogenic and resistant to antibiotics has increased in recent years. One of the bacteria that has experienced resistance is Staphyloccoccus aureus. Methicillin-Resistant Staphylococcus aureus (MRSA) is a strain of Staphylococcus aureus bacteria that resistants to the antibiotic methicillin. At present, vancomycin as the antibiotic of choice for the treatment of MRSA infections is reported to have decreased effectiveness. Many attempts have been made to develop alternative antibiotics. Clove (Syzygium aromaticum) is one of the native plants of Indonesia which has many benefits, including antibacterial. Eugenol, tannins, saponins, flavonoids, and alkaloids are the active components contained in cloves in inhibiting Methicillin-Resistant Staphylococcus aureus (MRSA) in vitro.


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Author Biography

Panggih Daru Panuluh, Universitas Lampung

Fakultas Kedokteran


Afifurrahman, Samadin KH, Aziz S. Pola kepekaan bakteri Staphylococcus aureus terhadap antibiotik vancomycin di RSUP Dr. Mohammad Hoesin Palembang. Majalah Kesehatan Sriwijaya. 2014; 46(4):266-70.

Azizah A, Suswati I, Agustin SM. Efek anti mikroba ekstrak bunga cengkeh (Syzygium aromaticum) terhadap

Methicillin Resistant Staphylococcus aureus (MRSA) secara in vitro. Jurnal Analis Kesehatan. 2017; 13(1):31-5.

Bao LM, Eerdunbayaer, Nozaki A, Takahashi E, Okamoto K, Ito H.. Hydrolysable tannins isolated from Syzygium aromaticum: structure of a new C-glucosidic ellagitannin and spectral features of tannins with a tergalloyl group. Heterocycles. 2012; 85(2):365–81.

Chen CJ, Huang YC. New epidemiology of Staphylococcus aureus infection in Asia. Clinical Microbiology Infection. 2014; 20:605-23.

Cushnie TP, Cushnie B, Lamb AJ. Alkaloids: An overview of their antibacterial, antibiotic- enhancing and antivirulence activities. International Journal of Antimicrobial Agents. 2014; 44:377-86.

Devi KP, Nisha SA, Sakthivel R, Pandian SK. Eugenol (essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane. Journal of Ethnopharmacology. 2010; 130(1):107 15.

EARS. Antimicrobial resistance surveillance in Europe. Stockholm: ECDC; 2013.

Huda M, Rodhiansyah, Ningsih DS. Efektivitas ekstrak bunga cengkeh (Eugenia aromatica) terhadap pertumbuhan bakteri Staphylococcus aureus. Jurnal Analis Kesehatan. 2018; 7(1):710-16.

Jirovetz L, Buchbauer G, Stoilova I, Stoyanova A, Krastanov A, Schmidt E. Chemical composition and antioxidant properties of clove leaf essential oil. Journal of Agricultural and Food Chemistry. 2006; 54 (17):6303–6307.

Juliantina FR, Citra DA, Nirwani B, Nurmasitoh T, Bowo ET. Manfaat sirih merah (Piper crocatum) sebagai agen anti bakterial terhadap bakteri gram positif dan gram negatif. Jurnal Kedokteran dan Kesehatan Indonesia. 2009; 1(1):12-20.

Kamatou GP, Vermaak I, Viljoen AM. Eugenol: from the remote Maluku Islands to the international market place: a review of a remarkable and versatile molecule. Molecules. 2012;17(6):6953–81. Mandal S, DebMandal M, Saha K, Pal NK. In vitro antibacterial activity of three Indian spices against Methicillin-Resistant Staphylococcus aureus. Oman Medical Journal. 2011; 26(5):319-23.

Mbaveng AT, Kuete V. Medicinal Spices and Vegetables from Africa. Cambridge: Academic Press; 2017.

Nuria MC, Faizatun A, Sumantri. UJI aktivitas antibakteri ekstrak etanol daun jarak pagar (Jatropha curcas L) terhadap bakteri Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, dan Salmonella typhi ATCC 1408. Mediagro. 2009; 5(2):26-37.

Oshomoh O E, Idu M, Udinyiwe O C. 2015. Phytochemical screening and antimicrobial sensitivity of clove fower (Syzygium aromaticum, L. Merrill and Perry) bud on dental pathogens. International Journal of Pharmacy and Pharmaceutical Research. 2015; 3(2):1-13.

Rojas DF, Souza CR, Oliveira WP. Clove (Syzygium aromaticum): a precious spice. Asian Pacific Journal of Tropical Biomedicine. 2014; 4(2):90-6.

Stryjewski ME, Corey GR. Methicillin-Resistant Staphylococcus aureus: an evolving pathogen. Clinical Infectious Diseases. 2014; 58(Suppl 1): S10–9.

Suwarto, Octavianty Y, Hermawati S. Top 15 tanaman perkebunan. Jakarta: Penebar Plus; 2014

Syahrurachman A, Chatim A, Soebandrio A, Karuniawati A. Buku ajar mikrobiologi kedokteran. Edisi revisi. Binarupa Aksara; 2010.

Thomas ANS. Tanaman obat tradisional. Yogyakarta: Kansas; 2007.

How to Cite
Panuluh, P. (2019). Potensi Cengkeh (Syzigium Aromaticum) sebagai Antibakteri Methicillin Resistant Staphylococcus Aureus (MRSA). Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 270-274. https://doi.org/10.35816/jiskh.v10i2.168

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