Peran Jintan Hitam (Nigella sativa) Sebagai Pengobatan Diabetes Mellitus

Intan Nanda Rezeki

  • Intan Nanda Rezeki Universitas Lampung
Keywords: Diabetes Mellitus, Nigella Sativa, Treatment


Diabetes mellitus (DM) is a disease characterized by an increase in glucose in the blood (hyperglycemia) and occurs when the pancreas does not produce insulin or when the body cannot effectively use insulin. The results of Indonesia Basic Health Research in 2018, showed the prevalence of DM in Indonesia increased and almost each province has increased. This is caused by unchanging risk factors such as sex, age, and genetic factors, the second is risk factors that can be changed such as smoking habits, education level, occupation, physical activity, smoking habits, alcohol consumption, body mass index, waist circumference and age. This disease is called the silent killer because it can affect all organs of the body and cause various kinds of complication. Management of it uses the four pillars such as educational management, lifestyle modification, exercise and the use of anti-diabetes drugs. However, herbal medicine is currently being developed to help overcome this degenerative disease in order to reduce the prevalence with using black cumin or Nigella Sativa. Black cumin is a plant that is high in fiber with a low glycemic index and contains high nutritional value including monosaccharides, rhamnose, xylose, arabinose, and non-starch polysaccharides. Black cumin can be processed into powder, extract or oil. Antidiabetic mechanisms of cumin seeds through the protective effect of beta cells on oxidative stress, induction of cell-â proliferation, reducing MDA levels in pancreatic tissue, decreasing plasma levels of the hormone leptin, increasing Glut-4 expression and decreasing gluconeogenesis in the liver.


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Author Biography

Intan Nanda Rezeki, Universitas Lampung

Pendidikan Dokter Fakultas Kedokteran


Abdulkhalek S, Hrynyk M, Szewczuk MR. (2013). A novel G-protein-coupled receptor-signaling platform and its targeted trainman himation in human disease, Research, and Reports in Biochemistry.

Aletta's, Zahran, dan Turkistany (2016). Nigella sativa and its active constituent thymoquinone in oral health. Saudi Med J. https://doi: 10.15537/smj.2016.3.13006

Alimohammadi S, Hobbenaghi R, Javanbakht J, Kheradmand D, Mortezaee R, Tavakoli M, et al. (2013). Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: An experimental study with histopathological evaluation. Diagn Pathol. https://doi: 10.1186/1746-1596-8-137

Samosa AO. (2015). A Review on the Hypoglycemic Effect of Nigella Sativa and Thymoquinone. Saudi Journal of Medicine & Medical Sciences. https:// DOI: 10.4103/1658-631X.149649.

Benhaddou-Andaloussi A, Martineau LC, Spoor D, Vuong T, Leduc C, Joly E, et al. (2009). Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic cells, skeletal muscle, and adipocytes. Pharm Biol.

Bradley R. (2018). Dietary Fat and Risk for Type 2 Diabetes: a Review of Recent Research. Curr Nutr Rep. https://doi: 10.1007/s13668-018-0244-z

Buraerah, Hakim. (2010). Analisis Faktor Risiko Diabetes Mellitus type 2 di Puskesmas Tanrutedong, Sidenreg Rappan Jurnal Ilmiah Nasional; 2010 [diakses 29 Agustus 2019].Tersedia dari : 61&src=a&id=186192

Eval dan Hammes. (2009). Cross-talk between G Protein-coupled and Epidermal Growth Factor Receptors Regulates Gonadotropin-mediated Steroidogenesis in Leydig Cells. J. Biol. Chem. https://doi: 10.1074/jbc.M803867200

Khatib H, Bamosa AO, Badar A, Al-Elq A, Abou-Hozaifa B, Lebda F. (2015). Nigella sativa Improves Glycemic Control and Ameliorates Oxidative Stress in Patients with Type 2 Diabetes Mellitus: Placebo-Controlled Participant Blinded Clinical Trial. PLOS ONE. https://doi: 10.1371/journal.pone.0113486.

Khan MA, Chen HC, Tania M, Zhang DZ. (2011). Anticancer activities of Nigella sativa (black cumin). Afr J Tradit Complement Altern Med. https://doi: 10.4314/ajtcam.v8i5S.

Mohtashami dan Entezari. (2016). Effects of Nigella sativa supplementation on blood parameters and anthropometric indices in adults: A systematic review of clinical trials. J Res Med Sci. https:// DOI: 10.4103/1735 1995.175154

Najmi A, Nasiruddin M, Khan RA, Haque SF. (2008). Effect of Nigella sativa Oil on Various Clinical and Biochemical Parameters of Insulin Resistance Syndrome. Int. J. Diab. Dev. Ctries. https://doi: 10.4103/0973-3930.41980.

Pari L, Sankaranarayanan C. (2009). Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin–nicotinamide induced diabetic rats. Life Sciences.

Riskesdas. Badan penelitian dan pengembangan kesehatan RI tahun 2013. Jakarta: Riskesdas, 2013.

Shabana A, El-Menyar A, Asim M, Al-Azzeh H, Al Thani H. (2013). Cardiovascular benefi ts of black cumin (Nigella sativa). Cardiovasc Toxicol. https://doi: 10.1007/s12012-012-9181-z.

Stewart AF, Hussain MA, Ocana AG, Vasavada RC, Bhusnan A, Bernal-Mizrachi E Kulkarni RN, Mizrachi EB. (2015). Human â-cell proliferation and intracellular signaling. Diabetes. htpps://doi: 10.2337/db14-1843.

WHO. (2016). Global report on diabetes. World health organization: Geneva.

Woo CC, Kumar AP, Sethi G, Tan KH. (2012). Thymoquinone: Potential cure for inflammatory disorders and cancer. Biochem Pharmacol. https://doi: 10.1016/j.bcp.2011.09.029.

Yenita. (2017). Uji Efektivitas Pemberian Minyak Jintan Hitam (Nigella sativa l.) terhadap Kadar Gula Darah Mencit Diabetes Mellitus yang Diberi Aloksan. Buletin Farmatera.

How to Cite
Rezeki, I. (2019). Peran Jintan Hitam (Nigella sativa) Sebagai Pengobatan Diabetes Mellitus. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 255-260. Retrieved from

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