Potensi Buah Pare (Momordhica Charantia) Sebagai Agen Pengobatan Ulkus Peptikum

Ellyta Septyarani

  • Ellyta Septyarani Universitas Lampung
Keywords: Pare, Pengobatan, Ulkus Peptikum

Abstract

Peptic ulcer is a condition of damage to the mucosal tissue, submucosa to the muscular layer of the digestive tract and is in direct contact with stomach acid / pepsin. The cause of peptic ulcers is related to H pylori and Non-steroidal Anti-Inflammatory Drugs (NSAIDs). H pylori infection accounts for 90% of duodenal ulcer and 70% -90% of gastric ulcer. A systematic eview in 2018 found Spain to have the highest annual incidence of 141.8 / 100,000 people, while Britain had the lowest of 23.9 / 100,000 people and the prevalence of peptic ulcer in Indonesia is 6-15% especially at the age of 20-50 years with a peak age of 50-60 years. Herbal plants are traditional medicines that have been used all over the world because they are easy to get, cheap, and can provide their own lessons. Currently being used the use of Pare (Momordhica charantia) as a Peptic Ulcer Treatment Agent.Topical injury initiates erosion of initiation by disrupting the defense of the gastric epithelial mucosa. Studies in mitochondria and various cells show the accumulation of 'ion trapping' or ions trapped in gastric epithelial cells with mitochondrial oxidative phosphorylation and the inhibition of the work of the electron transport chain. This results in no formation of intracellular ATP, cellular Ca ++ toxicity and buildup of Reactive Oxygen Species (ROS) as free radicals.Momordica charantia is a family plant of Cucurbitaceae which has leaves, flowers and fruit. This plant shows considerable activity in reducing oxidative stress caused by reactive oxygen species that can treat peptic ulcers.

Downloads

Download data is not yet available.

Author Biography

Ellyta Septyarani, Universitas Lampung

Fakultas Kedokteran

References

Azhari H, Underwood F, K. J. (2018). The global incidence of peptic ulcer disease and its complications at the turn of the 21st century;a systematic review. J Can Assoc Gastroenterol, 1(2), 61–62.

Brunicardi F.C., Andersen D.K., Billiar T.R., Dunn D.L., H. J. . et al. (2014). Schwartz’s principle of surgery. 9th ed. Houston: Mc Graw-Hill.

Cai S, Garcia Rodriguez LA, Masso-Gonzalez EL, H.-D. S. (2010). Uncomplicated peptic ulcer in the UK. Trends from 1997 to 2005. Aliment Pharmacol Ther, 30(10), 1039–1048.

Gill, N.S., S. Kaur, R. A. and M. B. (2011). Screening of antioxidant and antiulcer potential of Citrullus colocynthis methanolic seed extract. Res. J. Phytochem, 2, 98–106.

Kamath, C.C.; Vickers, K.S.; Ehrlich, A.; McGovern, L.; Johnson, J.; Singhal, V.; Paulo, R.; Hettinger, A.; Erwin, P.J.Montori, V. . (2010). Behavioral Interventions to Prevent Childhood Obesity: a Systematic Review and Metaanalyses Of Randomized Trials. The Journal Of Clinical Endocrinology & Metabolism, 93(13), 4606–4615.

Kautsar, A. (2019). Pengaruh Capsaicin pada Proses Penyembuhan Lambung Tikus yang Diberi Paparan Piroksikam. Skripsi. Fakultas Kedokteran Universitas Indonesia, Jakarta; 2009.

Kirtida, T., Shah B. K., D. S. (2013). A Study of Ulcer Healing Effect of Vegetable Plantain Banana (Musa sapientum var. paradisiacal) on Aspirin Induced Gastric Ulcer in Rats. International Journal of Research in Pharmaceutical and Biomedical Sciences, 4(1), 339–343.

Orrenius, S. (2010). Reactive Oxygen Species in Mitochondria-mediated Cell Death. Drug Metab Rev, 39, 443–55.

Rezaeizadeh, A., A.B.Z. Zuki, M. Abdollahi, Y.M. Goh, M.M. Noordin, M. H. and T. I. A. (2011). Determination of antioxidant activity in methanolic and chloroformic extracts of Momordica charantia. Afr. J. Biotechnol, 10, 4932–4940.

Robins KV dan Cotran RS. (2012). Buku Ajar Patologi Robbins, Edisi 7. Jakarta: EGC.

Sanusi, I. (2014). Tukak Lambung. Jakarta Selatan: Interna Publishing.

Sung JJ, Kuipers EJ, E.-S. H. (2019). Systematic review: the global incidence and prevalence of peptic ulcer disease. Aliment Pharmacol Ther, 29(9), 938–946.

Surendra, R. (2018). Herbal Treatment Alternatives For Peptic Ulcer Disease. Journal Of Drug Delivery & Therapeutics, 6(3), 27–33.

Tarigan P, A. H. (2016). Tukak Gaster dan Tukak Duodenum. Dalam: Buku Ajar Ilmu Penyakit Dalam Edisi Keempat - Jilid I. Jakarta: Pusat Penerbitan Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia.

WHO. (2014). World Health Rankings Indonesia Peptic Ulcer Disease [diakses tanggal 23 Agustus 2019.

Published
2019-12-30
How to Cite
Septyarani, E. (2019). Potensi Buah Pare (Momordhica Charantia) Sebagai Agen Pengobatan Ulkus Peptikum. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 222-225. Retrieved from https://akper-sandikarsa.e-journal.id/JIKSH/article/view/154
Section
Articles

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.