Efek Antimikroba Capsaicin

Carlos Taolin

  • Carlos Taolini Universitas Lampung
Keywords: Antimikroba, Capsaicin


Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is an active component of the Capsicum plant (chili), which is grown as food and for medicinal purposes since ancient times, and is responsible for the spiciness of the fruit. Capsaicin and related compounds (called capsaicinoids) are secondary metabolites of chili which play an important role in plant defense, possibly as an antidote to animals. In addition, there are several pharmacological and physiological properties (pain relief, cancer prevention, beneficial cardiovascular effects, and digestive effects. Capsaicin is an organic compound with a group of alkaloids available in large quantities in fruits from various chilies. Capsaicin has an impact on thermoregulation and metabolism. adipose tissue and is characterized by antioxidant, hypotensive and anticancer effects In general, capsaicinoids inhibit bacterial growth and metabolism, so this compound is also indicated to inhibit the process of biogas production at certain concentrations through the mechanism of bacterial membrane destruction


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Author Biography

Carlos Taolini, Universitas Lampung

Program Pendidikan Dokter Fakultas Kedokteran


Adaszek, Ł., Gadomska, D., Mazurek, Ł., Łyp, P., Madany, J., & Winiarczyk, S. (2019). Properties of capsaicin and its utility in veterinary and human medicine. Research in Veterinary Science. https://doi.org/10.1016/j.rvsc.2018.12.002

Alam, M. A., Syazwanie, N. F., Mahmod, N. H., Badaluddin, N. A., Mustafa, K. ‘Ain, Alias, N., … Prodhan, M. A (2018). Evaluation of antioxidant compounds, antioxidant activities and capsaicinoid compounds of Chili (Capsicum sp.) germplasms available in Malaysia. Journal of Applied Research on Medicinal and Aromatic Plants. https://doi.org/10.1016/j.jarmap.2018.02.001

Calvo-Irabien, L. M. (2018). Native Mexican aromatic flora and essential oils: Current research status, gaps in knowledge and agro-industrial potential. Industrial Crops and Products. https://doi.org/10.1016/j.indcrop.2017.11.044

Centers for Disease Control and Prevention. (2018). Biggest Threats and Data|Antibiotic/Antimicrobial Resistance | CDC. In November 26, 2018.

De, A. K., & De, M. (2019). Functional and Therapeutic Applications of Some Important Spices. In The Role of Functional Food Security in Global Health. https://doi.org/10.1016/b978-0-12-813148-0.00029-3

De Lourdes Reyes-Escogido, M., Gonzalez-Mondragon, E. G., & Vazquez-Tzompantzi, E. (2011). Chemical and pharmacological aspects of capsaicin. Molecules. https://doi.org/10.3390/molecules16021253

Gurnani, N., Gupta, M., Mehta, D., & Mehta, B. K. (2016). Chemical composition, total phenolic and flavonoid contents, and in vitro antimicrobial and antioxidant activities of crude extracts from red chilli seeds ( Capsicum frutescens L.) . Journal of Taibah University for Science. https://doi.org/10.1016/j.jtusci.2015.06.011

Kalia, N. P., Mahajan, P., Mehra, R., Nargotra, A., Sharma, J. P., Koul, S., & Khan, I. A. (2012). Capsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dks232

Luo, X. J., Peng, J., & Li, Y. J. (2011). Recent advances in the study on capsaicinoids and capsinoids. European

Journal of Pharmacology. https://doi.org/10.1016/j.ejphar.2010.09.074

Maksimova, V., Mirceski, V., Gulaboski, R., Gudeva, L. K., & Sarafinovska, Z. A. (2016). Electrochemical evaluation of the synergistic effect of the antioxidant activity of capsaicin and other bioactive compounds in Capsicum sp. extracts. International Journal of Electrochemical Science. https://doi.org/10.20964/2016.08.34

Marini, E., Magi, G., Mingoia, M., Pugnaloni, A., & Facinelli, B. (2015). Antimicrobial and anti- virulence activity of capsaicin against erythromycin-resistant, cell-invasive group A streptococci. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2015.01281

Srinivasan, K. (2016). Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review. Critical Reviews in Food Science and Nutrition. https://doi.org/10.1080/10408398.2013.772090

Wang, X., Yu, L. M., Li, F. C., Zhang, G. L., Zhou, W. J., & Jiang, X. H. (2019). Synthesis of amide derivatives containing capsaicin and their antioxidant and antibacterial activities. Journal of Food Biochemistry. https://doi.org/10.1111/jfbc.13061

Yamakawa, K., Matsuo, J., Okubo, T., Nakamura, S., & Yamaguchi, H. (2018). Impact of capsaicin, an active component of chili pepper, on pathogenic chlamydial growth (Chlamydia trachomatis and Chlamydia pneumoniae) in immortal human epithelial HeLa cells. Journal of Infection and Chemotherapy. https://doi.org/10.1016/j.jiac.2017.10.007

How to Cite
Taolini, C. (2019). Efek Antimikroba Capsaicin. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 212-216. https://doi.org/10.35816/jiskh.v10i2.152

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