Glutathione sebagai pemutih kulit

Vira Katya Aurelia

  • Vira Katya Aurelia Universitas Lampung


GSH is one of the compounds that inhibits melanin production by inhibiting tyrosinase activity. Antimelanogenic properties of glutathione have resulted in doctors often giving it as a "miracle" medicine for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. However, its uncontrolled use, especially as a parenteral formulation, seems unjustified, given the lack of research in supporting this theory. Although there are mechanisms that inhibit the process of melanogenesis by considering the side effects in the form of impaired liver function. Its safety as an intravenous drug is also questionable. The use of Gluthatione as a skin lightening agent, either topically, orally, or intravenously shows mixed results in an enlightening effect. Further research must be carried out to ensure the safe use of this substance, some studies report that oral use shows better effectiveness than topical or intravenous, but the side effects that are also dangerous such as impaired liver function


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Author Biography

Vira Katya Aurelia, Universitas Lampung

Fakultas Pendidikan Dokter Universitas Lampung


Amodu, M. O., M. T. Bolori, I. M. Ahmad, A. Kale, and A. Kuchichi. (2018). “Knowledge, Attitude and Practice of Skin Whitening among Female University Students in Northeastern Nigeria.” OALib.

Burger, Pauline, Anne Landreau, Stéphane Azoulay, Thomas Michel, and Xavier Fernandez. (2016). “Skin

Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners.” Cosmetics.

D’Mello, Stacey A. N., Graeme J. Finlay, Bruce C. Baguley, and Marjan E. Askarian-Amiri. (2016). “Signaling Pathways in Melanogenesis.” International Journal of Molecular Sciences 17(7):1–18.

Dilokthornsakul, Witoo, Teerapon Dhippayom, and Piyameth Dilokthornsakul. (2019). “The Clinical Effect of Glutathione on Skin Color and Other Related Skin Conditions: A Systematic Review.” Journal of Cosmetic Dermatology 18(3):728–37.

ElObeid, Adila Salih, Afaf Kamal-Eldin, Mohamed Anwar K. Abdelhalim, and Adil M. Haseeb. (2017). “Pharmacological Properties of Melanin and Its Function in Health.” Basic and Clinical Pharmacology and Toxicology 120(6):515–22.

Farahat, Al-Shaimaa A., ; Lamia, H. El-Garhy, Nageh A. El-Mahdy, and Basma M. Ali. (2018).

Evaluation of the Efficacy and Safety of Topical and Oral Glutathione in Treatment of Melasma. Vol. 86.

Pizzorno, Joseph. (2014). “Glutathione!” Integrative Medicine (Encinitas, Calif.) 13(1):8–12. Robinson,

Petra A. n.d. Perceptions of Beauty and Identity: The Skin Bleaching Phenomenon in


Sonthalia, Sidharth, Deepashree Daulatabad, and Rashmi Sarkar. (2016). “Glutathione as a Skin Whitening Agent: Facts, Myths, Evidence and Controversies.” Indian Journal of Dermatology, Venereology, and Leprology.

Sonthalia, Sidharth and Rashmi Sarkar. (2017). “Glutathione for Skin Lightning: An Update.”

Pigment International 4(1):3.

Sriharsha, M., P. Alekhya, T. Priya, Darsini K. Siva, and Teja Reddy. (2014). Gluthathione as a Whitening Agent in the Treatment of Melanos Is on Face. Vol. 1.

Watanabe, Fumiko, Erika Hashizume, Gertrude P. Chan, and Ayako Kamimura. (2014). “Skin- Whitening and Skin-Condition-Improving Effects of Topical Oxidized Glutathione: A Double- Blind and Placebo-Controlled Clinical Trial in Healthy Women.” Clinical, Cosmetic and Investigational Dermatology 7:267–74.

Watson, Meg, Dawn M. Holman, and Maryellen Maguire-Eisen. (2016). “Ultraviolet Radiation Exposure and Its Impact on Skin Cancer Risk.” Seminars in Oncology Nursing.

Weschawalit, Sinee, Siriwan Thongthip, Phanupong Phutrakool, and Pravit Asawanonda. (2017). “Clinical, Cosmetic and Investigational Dermatology Dovepress Glutathione and Its Antiaging and Antimelanogenic Effects.” Clinical, Cosmetic and Investigational Dermatology 10–147.

Zonunsanga. (2015). “Melanocytes and Melanogenesis.” Our Dermatology Online 6(3):350–55. Zubair, Shazia,

Sajia Hafeez, and Ghulam Mujtaba. (2016). “Efficacy of Intravenous Glutathione vs. Placebo for Skin Tone Lightening.” Journal of Pakistan Association of Dermatologists 26(3):177–81.

How to Cite
Aurelia, V. (2019). Glutathione sebagai pemutih kulit. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 138-142. Retrieved from